An important 18th century radical republican theorist and political writer, Thomas Paine was a leading figure in the American Revolution. Despite his humble beginnings and lack of formal education, his reasoned and persuasive writings not only influenced nascent American republican ideology, but profoundly affected the perception of government in England and France as well. His three most influential works are Common Sense (1776), The Rights of Man (1791-1792), and The Age of Reason (1794, 1795, 1807). The Richard Gimbel Collection is a heterogeneous mix of items connected only by the fact that they were all collected by Gimbel (1898-1970) and that most were written by, to, or about the revolutionary Paine. Of primary importance are the approximately sixty-five letters or manuscripts in Paine's own hand, including Paine's 1776 manuscript notes for Common Sense, his letter of January 10, 1781, in which he takes leave of his former commanding officer, Nathanael Greene, and his January 6, 1789 letter to Kitty Nicholson Few, in which he writes of his view of matrimony and other personal matters. The collection includes a series of correspondence between Thomas Paine and Samuel Adams, which were originally marked "forgeries," these appear instead simply to be the letters of two men bearing famous names.

A physician, natural historian, and professor at the University of Pennsylvania, Benjamin Smith Barton (1766-1815) was one of the central figures in Philadelphia's early national scientific establishment. Having received his medical training in European universities, Barton was appointed Professor at the University of Pennsylvania in 1789, lecturing on botany, materia medica, natural history. A prolific author, he established his reputation as one of the nation's preeminent botanists through his botanical text book The Elements of Botany (1803), but his contribtions to zoology, ethnology, and medicine were equally noteworthy. Barton's monograph on the "fascinating faculty" of the rattlesnake and his efforts in historical linguistics (New Views of the Origin of the Tribes and Nations of America, 1798) were widely read, and his Philadelphia Medical and Physical Journal (1804-1809) was one of the nation's first medical journals and an important outlet for natural historical research. The Barton Papers offer a comprehensive view of the professional work of Benjamin Smith Barton from the time of his return to the United States in 1789 until his death. The collection is divided into five series: Correspondence, Subject Files, Bound Volumes, Graphic Materials, and Printing Plates. The collection includes a particularly valuable series of botanical, medical, and natural historical drawings collected by Barton for research, reference, and publication. Among the many artists represented are William Bartram, Frederick Pursh, Pierre Turpin, and Benjamin Henry Latrobe.